RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Foxo3
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Mouse Lung Fibrosis Model; Human Lung Samples; Statistical Analysis etc.
Target
Foxo3a
Pathway
NA
PubMed ID
Title
MicroRNA-29c Prevents Pulmonary Fibrosis by Regulating Epithelial Cell Renewal and Apoptosis
Year
2017
Function
"MicroRNA-29c (MiR-29c) expression is lower in AEC2s of individuals with idiopathic pulmonary fibrosis (IPF) than healthy lungs. Epithelial cells overexpressing miR-29c show higher proliferative rate and viability. MiR-29c protects epithelial cells from apoptosis by targeting Foxo3a. Both overexpression of miR-29c conventionally and AEC2s specifically leads to less fibrosis and better recovery in vivo. MiR-29c maintains epithelial integrity and promotes recovery from lung injury, thereby attenuating lung fibrosis in mice."